Moebius Syndrome is a rare inherent neurological

Moebius Syndrome is a rare inherent neurological disorder which is shown through facial paralysis and the inability to move the eyes around. This syndrome is named after Paul Julius Möbius, a neurologist who first described the syndrome in 1888 as “..a man who had no facial expression, could not blink his eyes and could not move his eyes laterally.” (“Sequence”) von Graefe made a case of inherent facial diplegia in 1880 and was later defined by Möbius in 1888. Von Graefe and Möbius accepted only cases with inherent facial diplegia and bilateral abducens nerve palsies as constructing Möbius syndrome. In 1939, Henderson added cases with congenital, unilateral facial palsy. In 1979, Towfighi et al proposed a classification system for Möbius syndrome based on pathologic differences observed in studies of patients with the syndrome. The immediate origin of Moebius syndrome is remote and most cases occur irregularly. Research suggests a sequence of genetic and environmental fortuity aspects. Some cases pose an elevated risk of forwarding the disorder from parent to offspring. At a cellular level, moebius syndrome affects the facial muscles. People with Moebius syndrome experience weakness or complete paralysis of the facial muscles, trouble swallowing or sucking, difficulties with speech and frequent drooling, inability to form facial expressions, including smiling, frowning, raising eyebrows, puckering lips or closing eyes, cleft palate dental problems, hand and foot problems including club foot and missing or fused fingers, hearing problems, high palate, irritated and dry eyes, motor delays, chest wall and upper limb anomalies, and crossed eyes. (“Syndrome”) Moebius syndrome is autosomal meaning the chromosome that the disorder takes place in is not a sex chromosome. It is also recessive meaning the genes expressed are inherited from both parents that have recessive genes, otherwise if one was dominant, then the dominant gene would mask the recessive gene. “In an autosomal recessive disorder, a couple in which each parent carries one altered copy of the disease gene has a 25% chance of having a child with the condition with each pregnancy.” (“Moebius”) MmMMMMmmMmmm*awareness color is purple*Diagnosis of Moebius syndrome is made on the basis of clinical manifestation, especially the insufficiency of facial expression after the baby is born. Since specific genes involved in Moebius syndrome have not yet been diagnosed, molecular genetic experimentation is not available at this time, but we do know that the genes’ locus is on chromosomes 13, 3, and 10. Anyone can be affected by this disorder. It happens in the womb, so it only affects newborns. You can’t be affected at any other age. It can occur in both sexes, male or female and in can occur in any ethnicity. About only 2,000 individuals have this disorder worldwide. At this time, there is no cure for moebius syndrome. You can not prevent the syndrome from happening and as far as treatment goes, a patient’s doctor will design a treatment plan for the patient. Infants with moebius syndrome can’t breastfeed so they have to use alternatives such as, feeding tubes or nipple shields. People also can’t blink at certain times which can lead to dry eye and treatments for that include eye drops or surgery to partially close the eyelids. Speech- language therapy, so patients can express their feelings and respond to others. A static sling surgery is when the surgeon props up the child’s drooping skin and smile surgery gives the patients the ability to smile, but none of these treatments cure moebius syndrome. These are just some ways to care and treat someone with this disorder. In the medical community, research for what genes cause moebius syndrome, a cure for the syndrome, better treatment options, and a way to prevent the condition is being researched. As far as support goes for moebius syndrome there is a moebius syndrome foundation and their website is http://moebiussyndrome.org/ and there is a moebius syndrome awareness day which is on January 24th, the birth date of Paul Julius Möbius. Also, there are support groups all over the world provided by the Total Giving Foundation.