Development from studies to achieve low-tech, large-scale health

Development of MEMS based flow
sensor on flexible substrate – Realization of a polymer (PDMS) based
cardiovascular shear stress/ flow sensor using micro fabrication techniques on
catheter to monitor real-time blood flow for atherosclerosis diagnosis
satisfying sensitivity, biocompatibility and reliability requirements. The major
aim of this research is to develop catheter-based MEMS sensors to provide high
spatial and temporal resolution for real-time monitoring in the vasculature.

Separation and manipulation of cells
on Microfluidic Platform by Dielectrophoresis – Realization of an integrated
microfluidic device with planer electrodes for rapid and continuous separation
of biological cells in mixed cell population with high selectivity using
dielectrophoresis technique.

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MEMS based Biosensor for
Electrophysiological characterization of cells – Electrical impedance
spectroscopy (EIS) is used to study the electrochemical phenomena in cells and
the toxicological effects in the cells.

 

Over the past 20 years, cancer research in India has
grown in size and impact. Clinicians, scientists, and government and state
policy makers in India have championed cancer research, from studies to achieve
low-tech, large-scale health outcomes to some of the most advanced areas of
fundamental cancer science. In this paper, we frame public policy discussions
about cancer with use of an in-depth analysis of research publications from
India. Cancer research in India is a complex environment that needs to balance
public policy across many competing agendas. We identify major needs across
these environments such as those for increased research capacity and training
and protected time for clinical researchers; for more support from states and
enhanced collaborative funding programmes from government; for development of
national infrastructures across a range of domains (ie, clinical trials, tissue
banking, registries, etc); and for a streamlined and rational regulatory
environment. We also discuss improvements that should be made to translate
research into improvements in cancer outcomes and public health.

Department of Biotechnology (DBT), India Cancer
Biology task force will facilitate research collaborations, foster research and
bring the cancer experts together. DBT funds diverse categories of cancer
research in epidemiology, molecular biology, genomics, transcriptomics,
proteomics, epigenetics, genome wide association studies, biostatistics,
imaging, cell line and animal models. It will also serve as a portal for cancer
investigators to discuss and exchange research ideas. From a DBT perspective,
this database will allow the DBT and other agencies to identify and form
potential research consortia in order to formulate focused strategies to
investigate specific types of cancers. It will also make it simpler to monitor
and quantify achievements in the field of cancer biology and therapy.

       In National Institute for Biology in
India the Soft lithography based tools and devices
are emerging as an important means of studying/controlling the interaction
between cells and their microenvironment, and also as a means of economising
reagent usage in research and diagnostics. There is a strong interest among
researchers for the need to miniaturise devices, produce lab-on-chip designs,
and for substrate patterning. Polymer microfluidic devices, microstructures and
stamp have been recently utilised to explore hitherto unaddressable facets in
cell biology, cancer, cell differentiation, stem cell culture, imaging
experiments, diagnostics, etc.

They  provide technical expertise, SU8
photolithography and PDMS based devices currently, and will add more
capabilities over the period of three to five years. This facility will serve
as a seed point for the introduction of the technology to the broader Indian
scientific community.This facility will provide both design as well as
manufacturing capabilities to the users in these institutes as well as other
research institutes and entrepreneurs in India. More importantly we will engage
with the researchers to help in the design, optimisation and troubleshooting of
experiments.

In this context IIT Bombay contributed a lot in micro
chip for cell trapping and Sorting. The Cell sorting is the process of
separating a heterogeneous mixture of cells into several homogeneous fractions.
It can be used to identify rare, diseased cells present in a population of
healthy cells. Different cell types usually differ in their physical (e.g.
size, stiffness, etc.) and chemical (e.g. response to specific receptors)
properties. Cell sorters exploit this kind of inherent differences to separate
two cell populations from each other. In our lab, we are developing a micro pillar-based
sorting device to fractionate blood cells based on the difference in their biophysical
properties, such as, size, shape and deformability. Our device can separate
platelets from blood with a separation purity of >90%.

The Centre
for Cellular & Molecular Biology (CCMB) is a premier research organization
in frontier areas of modern biology. The objectives of the Centre are to
conduct high quality basic research and training in frontier areas of modern
biology, and promote centralized national facilities for new and modern
techniques in the inter-disciplinary areas of biology.

In Micro-Nano
fluidics various phenomena related to fluids, their interfaces and their
complex interactions with other soft / hard matter at micro-nano scale is
investigated. Behaviour of a fluid in such a tiny volume is quite different
from that of the bulk. For example, tiny volumes of liquid have higher pressure
than in bulk. Many of these differences arise from the increasing influence of
the fluid surface and surface forces at these scales. Dominance of these
surface forces at tiny scales enables some insects to walk on water. The
research in this area is focused on multiple interesting scientific problems
including interfacial dynamics, nano-swimmers, DNA sequencing &
bio-sensing, liquid-solid interfaces, probing cells in micro fluidic devices,
etc. These fundamental explorations are leading to technology solutions in the
fields of healthcare, water conservation, industrial / scientific metrology,
etc. Current research efforts at CeNSE in Micro-Nanofluidcs.

 

Centre for Nano
Science and Engineering completely focus on the research in Gallium Nitride. Due
to unique material properties such as high polarization, wide band gap, high
carrier mobility and velocity, Gallium Nitride and its alloys (III-nitride
family) have enabled devices with much superior performances in the areas of
high-power switching and RF transistors. Also, these alloys have revolutionized
solid-state lighting in the form of blue (white) LED, and are poised to make
disruptive changes in display, storage, biomedical and strategic technologies
in the form of green/blue LEDs, deep UV detectors and LEDs.GaN High Electron
mobility transistor (HEMT) for power electronics. A team of six to seven
faculty members affiliated to various departments spanning CeNSE, EE, power and
DESE are working on multi-disciplinary aspects of GaN technology for power
electronics starting from material growth to circuits and packaging. S.
Raghavan grows state-of-art GaN epi-layers while D. Nath and N. Bhat are
working on design, process and fabrication of high-power HEMTs (40 V, 5 A) to
enable DC-DC converters on indigenously developed GaN on silicon platform. Wide
periphery devices are being fabricated and characterization are underway.

Venkatesh A, Patel SK, Ray S, Shastri J,
Chatterjee G, Kochar SK, Patankar S, Srivastava S  have performed on Proteomics of Plasmodium vivax malaria: New insights,
progress and potential in 2016.
            Jha NN, Ghosh D, Das S, Anoop A,
Jacob RS, Singh PK, Ayyagari N, Namboothiri IN, Maji SK  have done the Effect of curcumin analogs on?-synuclein aggregation and
cytotoxicity. in 2016.
            In 2016  Rai V, Karthikaichamy A, Das D, Noronha S,
Wangikar PP, Srivastava S. have satisfied the Multi-omics Frontiers in Algal Research: Techniques and
Progress to Explore Biofuels in the Postgenomics World.
            In 2016, Chatterjee A, Ali F, Bange
D, Kondabagil K. performed  Complete Genome Sequence of a New Megavirus Family Member
Isolated from an Inland Water Lake for the First Time in India.
             Atak A, Mehta K, Rao A, Gollapalli K, Manubhai
KP, Gandhi M, Nayak M, Gahoi N, Reddy PJ, Jain R, Ghantasala S, Gupta S,
Mukherjee S, Pillai T, Singh VA, Mani VA, Pandey V, Srivastava S. have done Targeted Proteomics Workshop and International Symposium
(IIT Bombay, Mumbai, India): An Accelerator for Global Proteomics in 2016.
            Ray S, Patel SK, Venkatesh A  et.ai performed the Clinicopathological Analysis and Multipronged
Quantitative Proteomics Reveal Oxidative Stress and Cytoskeletal Proteins as
Possible Markers for Severe Vivax Malaria., in 
2016 .

An overview of innovations and
industrial solutions in Protein Microarray Technology is carried out by Gupta S, Manubhai KP, Kulkarni V,
Srivastava S.in  2016

In 2015 ,
Kumar S, Saragadam T, Punekar NS  exposed
a Novel Route for Agmatine Catabolism
in Aspergillus niger Involves 4-Guanidinobutyrase.
            Reddy PJ,
Sinha S, Ray S, Sathe GJ, Chatterjee A, Prasad TS, Dhali S, Srikanth R, Panda
D, Srivastava S. performed the Comprehensive analysis of temporal alterations in
cellular proteome of Bacillus subtilis under curcumin treatment.2015

In 2015 Adhikary RR, More P, Banerjee R. exposed
the Smart
nanoparticles as targeting platforms for HIV infections.